Kinetic Modeling of [11C]Raclopride: Combined PET-Microdialysis Studies
نویسندگان
چکیده
منابع مشابه
Tracer Kinetic Modeling in PET.
Molecular imaging using PET provides a unique tool for noninvasively investigating the biochemistry of living organs. The wide range of radiolabeled molecules makes it possible to explore various biochemical, physiologic, and pharmacologic processes in vivo. Because each radiotracer is characterized by its particular kinetic behavior in the human body, the quantification of this behavior is a c...
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Institute of Nuclear Medicine, University College London, London, UK Kinetic analysis can be applied both to dynamic PET and dynamic contrast enhanced (DCE) MRI data. We have investigated the potential of combined PET-MRI kinetic modelling using simulated FDG data. The volume of distribution, Ve, for the extravascular extra-cellular space (EES) can be estimated by DCE-MRI, and used to reduce th...
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UNLABELLED Because many drugs possess an intracellular site of action, the knowledge of intracellular concentration-time profiles is desirable. In the present study, PET, which measures total (i.e., intracellular, extracellular, and intravascular) concentrations of radiolabeled drugs in tissue, and microdialysis, which determines unbound drug concentrations in the extracellular space fluid of t...
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Kinetic modeling is the tool of choice when developing new positron emission tomography (PET) tracers for quantitative functional analysis. Several approaches are widely used to facilitate this process. While all these approaches are inherently different, they are still subject to uncertainty arising from various stages of the modeling process. In this paper we propose a novel approach for deri...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1997
ISSN: 0271-678X,1559-7016
DOI: 10.1097/00004647-199709000-00002